Enantioselective Prins cyclization: BINOL-derived phosphoric acid and CuCl synergistic catalysis.
نویسندگان
چکیده
The first catalytic enantioselective Prins cyclization is disclosed. The reaction is catalyzed by the combination of a chiral BINOL-derived bis-phosphoric acid and CuCl. The process consists of a tandem Prins/Friedel-Crafts cyclization that affords the hexahydro-1H-benzo[f]isochromenes products with three new contiguous stereogenic centers in high yields, and good enantio- and excellent diastereoselectivities.
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 56 شماره
صفحات -
تاریخ انتشار 2014